Significance We developed a statistical method that detects if shared ancestral genetic variants contribute to a disorder by analyzing common variant data from cohorts that include discordant sibling pairs. We applied this method to two published datasets of autism families and found strong evidence that shared ancestral genetic variants contribute to autism spectrum disorders.
No takes yet. Share an insight, caveat, or question.
Ye et al. (2017) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: