Key result
Among 85 females with PCOS, 78% were overweight or obese, 98% had hirsutism, and approximately 33% had metabolic syndrome, which was more prevalent in first-generation relatives.
Cross-Sectional (n=689)
No
A high prevalence of metabolic syndrome and obesity was observed in PCOS patients, with metabolic syndrome being more common in first-generation relatives.
Aims: Inheritance of polycystic ovary syndrome (PCOS) is still a controversy. Our study aims to analyze the family history of PCOS features and related metabolic disturbances including the male members to determine the mode of their inheritance. Study Design: A cross sectional study with convenient sampling. Place and Duration of Study: Department of Medicine, Kasturba Medical College, Mangalore between 2009 and 2012. Methodology: Demographic data such as body weight and age was recorded. Menstrual, obstetric and medical history of 85 PCOS females was collected. Presence of metabolic syndrome (MetS) was confirmed. Blood pressure and waist circumference were measured. Biochemical and hormonal estimations were done. Relevant information required for the study of 604 members of first and second generation relatives was collected. SPSS (version 17.0) was used to analyze the data. Results: Seventy eight percent of the PCOS patients were either overweight or obese and 98% of them had hirsutism. Approximately, 33% of them had MetS which was higher in the first generation
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Muralidhara et al. (2014) conducted a cross-sectional in Polycystic ovary syndrome (n=689). Family history of PCOS features and metabolic disturbances was evaluated on Metabolic syndrome (MetS) and PCOS features. Among 85 females with PCOS, 78% were overweight or obese, 98% had hirsutism, and approximately 33% had metabolic syndrome, which was more prevalent in first-generation relatives.
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