Key result
Isolated growth hormone deficiency demonstrated an autosomal dominant inheritance pattern in two affected families, indicating that the condition is genetically heterogeneous.
This report suggests that isolated growth hormone deficiency can be inherited in an autosomal dominant manner, highlighting its genetic heterogeneity.
May support genetic counseling in familial IGHD; leaves open broader inheritance patterns pending validation studies.
Two families, each with a father and a son affected by isolated growth hormone deficiency, are described. The inheritance in these cases seems to be due to an autosomal dominant gene. Isolated growth hormone deficiency appears to be a heterogeneous condition.
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Poskitt et al. (1974) studied this question. Isolated growth hormone deficiency demonstrated an autosomal dominant inheritance pattern in two affected families, indicating that the condition is genetically heterogeneous.
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