Key result
High concentrations of furosemide inhibited T4 binding in plasma in four critically ill patients, suggesting it may contribute to the low T4 state in critical illness.
Why the study?
Does high dose furosemide inhibit serum binding of thyroxine in patients with severe non-thyroidal illness?
Case Report (n=4)
Does high dose furosemide inhibit serum binding of thyroxine in patients with severe non-thyroidal illness?
High-dose furosemide can inhibit thyroxine binding to plasma proteins, potentially causing a low T4 state in critically ill patients.
No takes yet. Share an insight, caveat, or question.
Should not yet alter furosemide use in critical illness; leaves open a mechanism for low T4 states.
Stockigt et al. (1984) conducted a case report in Severe non-thyroidal illness with oliguric renal failure (n=4). High dose furosemide was evaluated on Inhibition of 125I T4 binding to plasma proteins. High concentrations of furosemide inhibited T4 binding in plasma in four critically ill patients, suggesting it may contribute to the low T4 state in critical illness.
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