Macroglobulinemia of Waldenström: A Review of the Literature and Presentation of a Case

Case Reports1 February 1956MACROGLOBULINEMIA OF WALDENSTRÖM: A REVIEW OF THE LITERATURE AND PRESENTATION OF A CASEALLAN E. VOIGT, M.D., PAUL G. FRICK, M.D.ALLAN E. VOIGT, M.D.Search for more papers by this author, PAUL G. FRICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-419 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMacroglobulinemia was first described as an entity by Waldenström in 1948,1 in discussing six patients seen by him in Upsala, Sweden. By means of ultracentrifugation of the patients' sera he was able to demonstrate the presence of a fraction in the serum proteins—presumably globulins—with molecular weights near 1,000,000, in contrast to the highest normal globulin molecular weights of 150,000.Other cases have been reported sporadically from Europe. In 1950 Tischendorf and Hartmann2reported one case, Bichel, Bing and Harboe3another. Schaub added three cases in 19524and one in 1953.6Habich5in 1953 studied the sero-immunologic properties of macroglobulins and...Bibliography1. Waldenström J: Two interesting syndromes with hyperglobulinemia, Schweiz. med. Wchnschr. 78: 927-928 (Sept. 25) 1948. MedlineGoogle Scholar2. TischendorfHartmann WF: Macroglobulinemia (Waldenström) with simultaneous hyperplasia of the tissue mast cells, Acta haemat. 40: 374, 1950. CrossrefGoogle Scholar3. BichelBingHarboe JJN: Another case of hyperglobulinemia and affection of central nervous system, Acta med. Scandinav. 138: 1-14, 1950. CrossrefMedlineGoogle Scholar4. Schaub F: Clinical picture and differential diagnosis of macroglobulinemia, Schweiz. med. Wchnschr. 82: 36 (Sept. 6) 1952. MedlineGoogle Scholar5. Habich H: Antigen analysis of paraprotein in macroglobulinemia, Schweiz. med. Wchnschr. 83: 51 (Dec. 19) 1953. MedlineGoogle Scholar6. Schaub F: Simultaneous appearance of Waldenström's macroglobulinemia and malignant tumors, Schweiz. med. Wchnschr. 83: 51 (Dec. 19) 1953. MedlineGoogle Scholar7. Schamaun M: Pathological anatomy of the so-called macroglobulinemia type Waldenström, Schweiz. Ztschr. allg. Path. 17: 24-46, 1954. MedlineGoogle Scholar8. Muller H: A case of macroglobulinemia; a contribution to the differential diagnosis of purpura hyperglobulinemica, München. med. Wchnschr. 96: 9 (Feb. 26) 1954. Google Scholar9. WildeHitzelberger HAL: Macroglobulinemia: clinical features and differential diagnosis, Blood 9: 9, 1954. CrossrefGoogle Scholar10. Mandema E: Waldenström's macroglobulinemia, Nederl. tijdschr. v. geneesk. 98: 29 (July 17) 1954. MedlineGoogle Scholar11. Dalgaard EB: Case of macroglobulinemia accompanied by atypical lymphatic hyperplasia, Acta path. et microbiol. Scandinav. 27: 506, 1950. CrossrefMedlineGoogle Scholar12. EsserSchmengler HF: Serum protein alteration in reticuloendotheliosis, Deutsche med. Wchnschr. 74: 1323, 1949. CrossrefGoogle Scholar13. BingNeel JA: Two cases of hyperglobulinemia with affection of the central nervous system on a toxi-infectious basis, Acta med. Scandinav. 88: 492, 1936. CrossrefGoogle Scholar14. BingFogNeel JMA: Report of a third case of hyperglobulinemia with affection of the central nervous system on a toxi-infectious basis, and some remarks on the differential diagnosis, Acta med. Scandinav. 91: 409, 1937. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication April 22, 1955.†Medical Fellow, Minneapolis General Hospital, Minneapolis, Minnesota.‡Instructor in Medicine, University of Minnesota Hospitals, Minneapolis, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWaldenström's Macroglobulinemia and Mononeuritis MultiplexE. WAYNE MASSEY, A. BERNARD PLEET, WILLIAM L BRANNONParaproteinämische HämoblastosenIrregular Blood CoagulationMacrocryogelglobulinemiaChromosomal abnormalities and oral anomaliesKlinische UntersuchungenWALDENSTRÖM'S MACROGLOBULINEMIA WITH CRYOGLOBULINEMIA*MARJORIE S. SIRRIDGE, M.D.Oral manifestations of macroglobulinemia of WaldenströmPlasma-Cell MyelomaMACROGLOBULINS AND MACROGLOBULINAMIAMACROGLOBULINEMIA: REPORT OF TWO CASES*HARRY GLENCHUR, M.D., HORACE H. ZINNEMAN, M.D., F.A.C.P., DAVID R. BRIGGS, Ph.D.Macroglobulinemia of waldenströmDie MakroglobulinämieInterference of abnormal plasma proteins with the clotting mechanism 1 February 1956Volume 44, Issue 2Page: 419-425KeywordsAnemiaBiochemistryBlood banksGastroenterology and hepatologyGlobulinsHemorrhageHospital medicineHyperglobulinemiaSerum proteinsUltracentrifugation Issue Published: 1 February 1956 PDF downloadLoading ...