Key result
The HTLV-1 accessory protein p8 induces cellular conduits that facilitate an additional mode of viral cell-to-cell transmission.
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Highlights a newly identified mode of HTLV-1 transmission via cellular conduits induced by the p8 protein.
Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8.
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Malbec et al. (2011) conducted a review in HTLV-1 infection. HTLV-1 p8 protein was evaluated on Cellular conduits for HTLV-1 transmission. The HTLV-1 accessory protein p8 induces cellular conduits that facilitate an additional mode of viral cell-to-cell transmission.
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