Key result
Molecular autopsy is a critical approach to uncover pathogenic inheritable conditions in cases of sudden unexplained death when traditional autopsy yields negative results.
Why the study?
Does molecular autopsy help identify the cause of sudden unexpected death in cases with a negative traditional autopsy?
Does molecular autopsy help identify the cause of sudden unexpected death in cases with a negative traditional autopsy?
Molecular autopsy is a critical tool for identifying inherited arrhythmogenic syndromes in cases of sudden unexplained death, aiding in diagnosis and enabling preventive care for surviving at-risk relatives.
May support NGS molecular autopsy in young sudden death; leaves open prospective validation of yield and family outcomes.
IntroductionSudden cardiac death (SCD) is defined as a natural unexpected death without an obvious noncardiac cause arising within 1 hour of onset of symptom, while in unwitnessed settings the natural unexpected death occurs within 24 hours of last being observed in normal health. 1 Adult sudden fatalities are primarily brought on by terminal ventricular arrhythmias and atherosclerotic coronary artery disease. 2 Aortic dissection, myocarditis, hypertrophic cardiomyopathy, congenital coronary artery anomali-
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Patil et al. (2023) conducted a review in Sudden Unexpected Death (SUD) and Sudden Cardiac Death (SCD). Molecular autopsy (post-mortem genetic testing) was evaluated. Molecular autopsy is a critical approach to uncover pathogenic inheritable conditions in cases of sudden unexplained death when traditional autopsy yields negative results.
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