Key result
Shohangekabukuryo-to (TJ-21) at 2 g/kg/day significantly prolonged the median survival time of fully allogeneic cardiac grafts in mice to 77 days compared to 8 days in untreated controls.
Why the study?
Does Shohangekabukuryo-to (TJ-21) prolong survival of fully allogeneic cardiac grafts in mice?
Does Shohangekabukuryo-to (TJ-21) prolong survival of fully allogeneic cardiac grafts in mice?
The herbal medicine Shohangekabukuryo-to (TJ-21) significantly prolonged the survival of fully allogeneic cardiac grafts in mice by inducing regulatory T cells and altering the Th1/Th2 cytokine balance.
Objective: Shohangekabukuryo-to (Tsumura Japan [TJ]-21) is well known as an herbal medicine with few side effects to treat vomiting, nausea, acute and chronic gastritis, and hyperemesis of pregnancy in Japan. In this study, we performed fully allogeneic cardiac grafts in mice to investigate the effect of TJ-21 on alloimmune responses.
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Yin et al. (2015) studied Cardiac allograft rejection. Shohangekabukuryo-to (TJ-21) vs. Untreated or distilled water was evaluated on Median survival time of cardiac allografts (p=<0.01). Shohangekabukuryo-to (TJ-21) at 2 g/kg/day significantly prolonged the median survival time of fully allogeneic cardiac grafts in mice to 77 days compared to 8 days in untreated controls.
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