[2,3]-Sigmatropic Rearrangement of Arylhydroxylamines: Rapid Access to ortho-Sulfonylated Anilines

This is the authors' abstract. We don't add key points for this paper.

In the absence of transition-metal catalysts and additional oxidants, arylhydroxylamines can undergo an unconventional O-sulfinylation/[2,3]-sigmatropic rearrangement/rearomatization cascade with trifluoromethylsulfinyl chloride to rapidly and efficiently synthesize versatile ortho-sulfonylated aromatic amines. This Synpacts article describes the discovery, further study, and practical application of the rearrangement reactions in arylhydroxylamine compounds and highlights our recent advances in this area. 1 Introduction 2 Discovery of a New Reaction 3 O-Sulfinylation of Arylhydroxylamines Followed by [2,3]-σ Rearrangement 4 Conclusion