Key result
Among 637 children under 15 years with acute flaccid paralysis in Korea, non-polio enterovirus was detected in 33.4% of cases, with EV-A71 comprising 54.9% of the positive samples.
Why the study?
The risk of polio importation and re-emergence persists, prompting an analysis of AFP surveillance in Korea to assess surveillance quality and understand the etiology of non-polio enterovirus-associated central nervous system diseases in a polio-free area.
Observational (n=637)
EV-A71 is a major causative agent of non-polio enterovirus-associated acute flaccid paralysis in children in Korea.
Answers are grounded in this paper and cite their sources.
EV-A71 predominance in NPEV-positive AFP supports targeted surveillance in Korean children; extends regional data but leaves causal and preventive implications open.
The risk of polio importation and re-emergence persists since epidemic polio still occurs in some countries, and the resurgence of polio occurring almost 20 years after polio eradication was declared in Asia has been reported. We analyzed the results of acute flaccid paralysis (AFP) surveillance in Korea to assess the quality of AFP surveillance and understand the etiology of non-polio enterovirus (NPEV)-associated central nervous system diseases in a polio-free area. We investigated 637 AFP patients under 15 years of age whose cases were confirmed during 2012-2019 by virus isolation, real-time reverse transcription polymerase chain reaction, and VP1 gene sequencing. Among the 637 AFP cases, NPEV was detected in 213 (33.4%) patients, with the majority observed in EV-A71, with 54.9% of NPEV positives. EV-A71 has been shown to play a role as a major causative agent in most neurological diseases except for Guillain-Barré syndrome (GBS), acute disseminated encephalomyelitis (ADEM), and meningitis. This study provides information on the AFP surveillance situation in Korea and highlights the polio eradication stage in the monitoring and characterization of NPEV against the outbreak of neurological infectious diseases such as polio.
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Yoon et al. (2021) conducted an observational in Acute flaccid paralysis (n=637). Non-polio enterovirus (NPEV) was evaluated on Detection of non-polio enterovirus (NPEV). Among 637 children under 15 years with acute flaccid paralysis in Korea, non-polio enterovirus was detected in 33.4% of cases, with EV-A71 comprising 54.9% of the positive samples.
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