Many physicians have overlooked the value of adding zinc chloride tissue fixation prior to Mohs micrographic surgery, partly because of the absence of randomized clinical comparison trials. Nevertheless, historic control data indicate a survival benefit in the treatment of cutaneous melanoma. Three possible mechanisms are: 1) prevention of release of viable cells into circulation during surgery, 2) avoidance of disruption of clinically invisible satellite deposits, and 3) stimulation of a local inflammatory reaction and possible immune response.
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Norman A. Brooks (1992) studied this question.
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