Key result
In head and neck cancer patients, 3DCRT and female sex were associated with a greater fall in blood pressure during radiotherapy, which strongly correlated with >10% weight loss (p=0.03).
Why the study?
The study was conducted to evaluate patterns of blood pressure changes in patients with head and neck cancer receiving radiation or chemo-radiation.
How does blood pressure change in patients with head and neck cancer receiving radiotherapy or chemo-radiotherapy?
Observational (n=451)
No
How does blood pressure change in patients with head and neck cancer receiving radiotherapy or chemo-radiotherapy?
Blood pressure significantly decreases during radiotherapy or chemo-radiotherapy for head and neck cancer, varying by treatment technique and sex, and is strongly associated with significant weight loss.
Answers are grounded in this paper and cite their sources.
BP monitoring and nutritional support may warrant attention during head and neck radiotherapy; leaves open causal effects and technique optimization.
BACKGROUND: To evaluate patterns of blood pressure (BP) changes in patients with head and neck cancer (HNC) receiving radiation (RT)/chemo-radiation (CRT) METHODS: This study included data collection, compilation, and analysis of 451 consecutive HNC patients who underwent RT/CRT. RESULTS: Out of 451 patients, 376 (82%) were male and 75 (18%) were female with a median age of 52 years. Patients receiving 3DCRT experienced greater fall in BP, including for SBP and MAP, compared to those receiving IMRT-IGRT. Female patients experienced greater fall in diastolic BP as compared to male patients (p: 0.03). At the end of treatment, we observed a significant association between a fall in systolic BP (decrease by 10% of baseline) and weight loss of more than 10% of baseline weight (p: 0.03). CONCLUSION: Fall in BP during RT/CRT is significantly affected by treatment technique and sex and is strongly associated with significant weight loss.
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Pandit et al. (2020) conducted an observational in Head and neck cancer (n=451). Radiotherapy or chemo-radiotherapy was evaluated on Patterns of blood pressure changes. In head and neck cancer patients, 3DCRT and female sex were associated with a greater fall in blood pressure during radiotherapy, which strongly correlated with >10% weight loss (p=0.03).
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