The chromatographic behavior of multiply charged analytes in ion interaction chromatography (IIC) was theoretically investigated. Practical equations that describe the relationship between the retention factor and the concentration of the ion interaction reagent (IIR) were developed. They can be used to model analyte retention as a function of both the mobile and stationary phase concentrations of the IIR. A comparison between the retention behaviour of singly and doubly charged analytes is given.
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Cecchi et al. (2004) studied this question.
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