Key result
First-day postoperative serum magnesium was an isolated predictor for the need for calcium replacement (OR 0.0004), with a 1.8 mg/dL cut-off yielding 78.1% sensitivity and 87.5% specificity.
Why the study?
The study was conducted to assess the ability of serum magnesium measured on the first postoperative day to predict the need for calcium replacement in patients undergoing total thyroidectomy.
Does serum magnesium measured on the first postoperative day predict the need for calcium replacement in patients undergoing total thyroidectomy?
Cohort (n=80)
No
Does serum magnesium measured on the first postoperative day predict the need for calcium replacement in patients undergoing total thyroidectomy?
Serum magnesium measured on the first postoperative day is an independent predictor of the need for calcium replacement after total thyroidectomy, offering a potential screening tool for early hospital discharge.
Mg1PO may flag calcium replacement need after thyroidectomy; leaves open prospective validation before guiding discharge.
Objective: Our aim was to assess the ability of serum magnesium (Mg), measured on the first postoperative day (Mg1PO), to predict the need for calcium (Ca) replacement in patients undergoing total thyroidectomy (TT). Subjects and methods: Eighty patients undergoing TT, with Mg1PO and PTH dosage in the first (PTH1h) and eighth (PTH8h) hours after TT, were evaluated for the need for Ca replacement. Data were evaluated by uni/multivariate logistic regression and Receiver Operating Characteristic (ROC) curve. Results: 32 patients (40%) required Ca replacement. Median PTH1h, PTH8h and Mg1PO were higher in the no replacement group: 17 versus (vs) 3 pg/mL (p < 0.001), 18.2 vs 3.0 pg/mL (p < 0.001) and 2 vs 1.6 mg/dL (p < 0.001), respectively. Mg1PO was the isolated predictor for this replacement (odds ratio = 0.0004, 95% confidence interval: 0.000003-0.04; p = 0.001), with the cut-off value of 1.8 mg/dL showing sensitivity and specificity of 78.1% and 87.5%, respectively. Conclusion: In this group of patients, serum Mg1PO was the isolated predictor for the need for Ca replacement.
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Soares et al. (2023) conducted a cohort in Total thyroidectomy (n=80). Serum magnesium on the first postoperative day (Mg1PO) vs. Lower serum magnesium levels was evaluated on Need for calcium replacement (OR 0.0004, 95% CI 0.000003-0.04, p=0.001). First-day postoperative serum magnesium was an isolated predictor for the need for calcium replacement (OR 0.0004), with a 1.8 mg/dL cut-off yielding 78.1% sensitivity and 87.5% specificity.
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