Key result
Oral glucose uptake significantly reduced circulating leptin levels after 2 hours in slim, insulin-sensitive adults, while adiponectin, resistin, CORS-26, and omentin levels remained unchanged.
Why the study?
Does an oral glucose load alter plasma levels of leptin, adiponectin, resistin, CORS-26, and omentin in healthy slim adults?
Population
20 healthy subjects, weight range 55-86 kg, mean BMI 22.5 ± 2 kg/m2, mean age 22.2 ± 0.5 years, highly…
Comparison
75 g oral glucose dissolved in 300 ml water vs Baseline (fasting state before glucose load)
Design
Cohort
Follow-up
120 minutes
Authors
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Does not support changing adipokine assessment after glucose loads in practice; hypothesis-generating for acute leptin regulation in metabolic research.
Observational (n=20)
No
Does an oral glucose load alter plasma levels of leptin, adiponectin, resistin, CORS-26, and omentin in healthy slim adults?
Absolute Event Rate: 2.5% vs 3%
p-value: p=0.0003
In healthy, insulin-sensitive adults, an oral glucose load acutely reduces circulating leptin levels but does not alter adiponectin, resistin, CORS-26, or omentin levels.
Wurm et al. (2007) conducted an observational in Healthy, slim, highly insulin-sensitive adults (n=20). Oral glucose load vs. Fasting state (baseline) was evaluated on Plasma leptin levels (ng/ml) (p=0.0003). Oral glucose uptake significantly reduced circulating leptin levels after 2 hours in slim, insulin-sensitive adults, while adiponectin, resistin, CORS-26, and omentin levels remained unchanged.
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