A Review: Steam Sterilization a Method of Sterilization

Sterilization is a process to removal of all living cells from an object including, viruses, spores, viroids and prions.Several sterilization principles exist according to the lethal agent used.Each treatment destroys microorganisms in a unique manner and with a different degree of effectiveness.As heat sterilization with dry or moist heat method, Radiation sterilization with gamma and X-rays which produce positively charged ions in their passage through mater, there by further generating free radicals with lethal effects in the cells, chemical sterilization with chemical reaction method, filtration sterilization which physically removes microorganisms forms the products by means of retentive filters.In this describe for steam sterilization method and its evaluation parameter, which help in most of pharmaceutical industry.Basic principle of steam destroy organism by coagulating the cell protein under heat and pressure.Generally moist heat sterilization is performed at 121 0 C under 15psig.FO, D and Z value which are used in validation process of all type of sterilization method.