Key result
Human umbilical cord mesenchymal stem cell-derived exosomes alleviated CVB3-induced myocarditis by activating the AMPK/mTOR-mediated autophagy flux pathway to attenuate cardiomyocyte apoptosis.
Why the study?
Human umbilical cord mesenchymal stem cell-derived exosomes show potential for tissue repair, but their effects on coxsackievirus B3-induced myocarditis remained unknown.
Do hucMSC-exosomes alleviate CVB3-induced myocarditis in preclinical models?
Do hucMSC-exosomes alleviate CVB3-induced myocarditis in preclinical models?
hucMSC-exosomes alleviate CVB3-induced myocarditis in preclinical models by activating the AMPK/mTOR-mediated autophagy flux pathway to attenuate cardiomyocyte apoptosis.
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Hypothesis-generating for hucMSC-exosome therapy in viral myocarditis; human trials required before any clinical consideration.
Gu et al. (2020) studied Coxsackievirus B3 (CVB3)-induced myocarditis. Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-exosomes) was evaluated on Myocardial pathology injury, proinflammatory cytokines, cardiac function, and apoptosis. Human umbilical cord mesenchymal stem cell-derived exosomes alleviated CVB3-induced myocarditis by activating the AMPK/mTOR-mediated autophagy flux pathway to attenuate cardiomyocyte apoptosis.
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