⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 1, 2011Genome biologyOpen Access

What does biologically meaningful mean? A perspective on gene regulatory network validation

Albertha J.M. Walhout

View Full Paper

Ask AI

Bookmark

Share

Abstract

Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Albertha J.M. Walhout (2011) studied this question.

synapsesocial.com/papers/6a9a0f246f891be7b24d47ce https://doi.org/10.1186/gb-2011-12-4-109

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Theory and Limitations of Genetic Network Inference from Microarray DataReview · 2007 · 105 citations
2Gene-centered regulatory networksOriginal Research · 2009 · 49 citations
3Unraveling transcription regulatory networks by protein–DNA and protein–protein interaction mappingOriginal Research · 2006 · 153 citations
4Unbiased reconstruction of a mammalian transcriptional network mediating the differential response to pathogensOriginal Research · 2009 · 5 citations
5Whole-genome ChIP–chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryoOriginal Research · 2007 · 288 citations