Key result
N-sulfonylanthranilic acid derivatives selectively inhibited Dengue virus RNA-dependent RNA polymerase by blocking the RNA tunnel, with the lead compound NITD-2 demonstrating an IC50 of 0.7 μM.
Population
Dengue virus (DENV) RNA-dependent RNA polymerase (RdRp) in biochemical assays
Comparison
N-sulfonylanthranilic acid derivatives vs WNV RdRp, hepatitis C virus RdRp, and human DNA…
Design
Preclinical
Authors
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May guide preclinical dengue antiviral development; leaves open translation to human efficacy and safety.
Effect estimate: IC50 0.7 μM
N-sulfonylanthranilic acid derivatives act as specific allosteric inhibitors of Dengue virus RdRp by blocking the RNA template tunnel, providing a potential target for antiviral development.
Niyomrattanakit et al. (2010) studied Dengue virus infection. N-sulfonylanthranilic acid derivatives (NITD-2) was evaluated on DENV RdRp activity inhibition (IC50) (IC50 0.7 μM). N-sulfonylanthranilic acid derivatives selectively inhibited Dengue virus RNA-dependent RNA polymerase by blocking the RNA tunnel, with the lead compound NITD-2 demonstrating an IC50 of 0.7 μM.
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