Variation of Perioperative Prophylactic Antimicrobial Use According to Regions and Procedures in Japan: A Descriptive Study Using Diagnosis Procedure Combination Data

Introduction: Globally, the inappropriate use of antimicrobials has led to the spread of drug-resistant bacteria, which show strong resistance to first-line antimicrobials. In Japan, a high proportion of broad-spectrum antimicrobials, which are effective against many types of bacteria, are used; their use is believed to be related to the increase in the number of multidrug-resistant bacteria.