Key result
A cardiac troponin I level greater than 89 ng/mL at 12 hours after symptom onset predicted the presence of early microvascular obstruction with a sensitivity of 63% and specificity of 88%.
Why the study?
Does plasma cardiac troponin I level correlate with and predict microvascular obstruction assessed by 3-T MRI in patients with acute STEMI?
Observational (n=51)
Single-blind (image analysis)
No
Does plasma cardiac troponin I level correlate with and predict microvascular obstruction assessed by 3-T MRI in patients with acute STEMI?
Effect estimate: AUC 0.766 (95% CI 0.6-0.88)
p-value: p=0.0002
A single plasma troponin I measurement at 12 hours post-STEMI can reliably predict the presence of microvascular obstruction, offering an accessible prognostic marker for adverse left ventricular remodeling.
No takes yet. Share an insight, caveat, or question.
May identify STEMI patients with microvascular obstruction; hypothesis-generating and requires prospective validation before clinical use.
Siquier-Pernet et al. (2014) conducted an observational in ST-segment-elevation myocardial infarction (STEMI) (n=51). Plasma cardiac troponin I (cTnI) levels was evaluated on Prediction of microvascular obstruction (MVO) at day 5 using cTnI at 12 hours (AUC 0.766, 95% CI 0.6-0.88, p=0.0002). A cardiac troponin I level greater than 89 ng/mL at 12 hours after symptom onset predicted the presence of early microvascular obstruction with a sensitivity of 63% and specificity of 88%.
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