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May 14, 2008ChemMedChem

Computational Design and Discovery of Conformationally Flexible Inhibitors of Acetohydroxyacid Synthase to Overcome Drug Resistance Associated with the W586L Mutation

Feng‐Qin Ji Cong‐Wei Niu Chao‐Nan Chen Qiong Chen Guang‐Fu Yang Zhen Xi Chang‐Guo Zhan

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Abstract

Rational design: A series of 2-aroxyl-1,2,4-triazolo[1,5-c]pyrimidine derivatives were computationally designed (see scheme) and synthesized as conformationally flexible AHAS inhibitors. These compounds could find use as new leads for combating drug resistance.

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Ji et al. (2008) studied this question.

synapsesocial.com/papers/6a9a18d53984bcb448b50470 https://doi.org/10.1002/cmdc.200800103

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