Key result
Metabolic and bariatric surgery in patients with class I obesity achieves 15.8-33.7% total weight loss and type 2 diabetes remission rates frequently exceeding 60%, with low complication rates.
Why the study?
Traditional guidelines historically excluded patients with class I obesity from metabolic bariatric surgery, but recent consensus has expanded eligibility for those with refractory comorbidities.
Does metabolic bariatric surgery improve weight loss and metabolic outcomes in patients with class I obesity (BMI 30-34.9 kg/m2)?
Does metabolic bariatric surgery improve weight loss and metabolic outcomes in patients with class I obesity (BMI 30-34.9 kg/m2)?
Metabolic and bariatric surgery is an effective and safe treatment for weight loss and comorbidity remission in patients with class I obesity, supporting recent guideline updates expanding surgical eligibility.
) constitutes a considerable portion of the global obesity burden; however, traditional guidelines for metabolic bariatric surgery (MBS) have historically excluded this population. Recent updates in clinical consensus have expanded surgical eligibility, particularly for patients with obesity-related comorbidities refractory to medical treatment. To synthesize evidence from clinical studies, international guidelines, and expert consensus to assess the efficacy, safety, and long-term outcomes of MBS in patients with class I obesity. A comprehensive literature review was conducted, incorporating major clinical trials, observational cohorts, and meta-analyses published between 2006 and 2024. Weight loss, metabolic outcomes, and major surgical complication rates were examined. Recent studies demonstrate that MBS in patients with class I obesity achieves a total weight loss of 15.8-33.7%, and excess weight loss up to 102.7%, with type 2 diabetes mellitus remission rates frequently exceeding 60%. Complication rates remain low and are comparable to those observed in cohorts with higher BMI. Indirect comparisons suggest that the metabolic benefits and safety profiles in class I obesity are comparable to those in patients with higher BMI. Updated guidelines from international bariatric societies support MBS in class I obesity. MBS is an effective and safe treatment for weight loss and remission of comorbidities in class I obesity. Supported by recent guidelines and expert consensus, it should be considered as a valid treatment option for appropriately selected patients, with the potential to reduce their long-term healthcare burden.
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Lee et al. (2025) conducted a review in Class I Obesity. Metabolic and bariatric surgery vs. Nonsurgical interventions or higher BMI cohorts was evaluated on Weight loss and type 2 diabetes remission. Metabolic and bariatric surgery in patients with class I obesity achieves 15.8-33.7% total weight loss and type 2 diabetes remission rates frequently exceeding 60%, with low complication rates.
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