The frequency of human platelet antigen (HPA) genotypes in the Polish population

The human platelet antigens (HPA1-5) in the Polish population were investigated using the PCR with sequence specific primers (SSP). The HPA gene frequency was: 1a--0.874, 1b--0.126; 2a--0.898, 2b--0.102; 3a--0.592, 3b--0.408; 4a--1.00, 4b--0.00; 5a--0.937, 5b--0.063. The HPA2 and HPA5 differed from those observed in some other European populations-German and both German and Austrian, respectively. The HPA5 alleles frequency was most similar to those observed in the Finnish population. The modification of SSP described allowed the genotyping of HPA1-4 under the same PCR conditions.