In the present work, the relative toxicity of 12 cultivars of raw dry beans was studied. When raw dry bean flours were given in the diets as the only source of protein the Wistar rats died within 3.8 (Goiano Precoce) to 8.4 days (Aroana). When whole seed flour was mixed with casein, strong impairment to ration utilization and animal development was observed, which was measured as loss of weigh:, decreased protein digestibility, decreased biological value and net protein utilization. A positive and significant correlation between toxicity and hemagglutination activity was established. On the other hand, antitryptic activity and tannin content did not show any correlation with the toxic effect. The deterimental effect of the lectins was evident by their interaction with the intestinal mucosa, which resulted in rupture of intestinal villii thus causing interference with absorption. These effects, when strong and prolonged, can cause the rat's death, in spite of the rat's adaptive and recovering capacity.
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Durigan et al. (1987) studied this question.
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