Key result
Neither moderate preeclampsia nor maternal dietary supplementation with cod-liver oil had any significant effect on the vasoactive response to PGF(2alpha) in human umbilical cord arteries.
Why the study?
Does preeclampsia or maternal omega-3 fatty acid supplementation alter the vasoactive effect of prostaglandin F(2alpha) in human umbilical arteries?
Observational
Does preeclampsia or maternal omega-3 fatty acid supplementation alter the vasoactive effect of prostaglandin F(2alpha) in human umbilical arteries?
Maternal omega-3 supplementation and moderate preeclampsia do not significantly alter the vasoactive response to prostaglandin F2alpha in human umbilical arteries.
No effect on umbilical artery reactivity; leaves open whether omega-3 influences other vascular or clinical pregnancy outcomes.
The vasoactive effect of prostaglandin F(2alpha) (PGF(2alpha)) was studied in in vitro perfused human umbilical arteries following maternal dietary supplementation with omega-3 fatty acids or in pregnancies complicated by a moderate degree of preeclampsia. In most preparations PGF(2alpha) induced a biphasic pressure response with a transient dilatation followed by a constrictory response. The pressure increase was significant in both groups, but no significant differences in the constrictory response or in the proportions of preparations displaying dilatatory responses were observed when compared to appropriate control groups. In conclusion, neither preeclampsia nor dietary supplementation with cod-liver oil had any significant effect on the vasoactive response to PGF(2alpha) in umbilical cord arteries.
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Haugen et al. (2001) conducted an observational in Pregnancy. Maternal dietary supplementation with omega-3 fatty acids or moderate preeclampsia vs. Appropriate control groups was evaluated on Vasoactive response to PGF(2alpha). Neither moderate preeclampsia nor maternal dietary supplementation with cod-liver oil had any significant effect on the vasoactive response to PGF(2alpha) in human umbilical cord arteries.
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