A total synthesis of hog thyrocalcitonin is described. A protected C‐terminal tridecapeptide amid (20–32) was coupled with a protected central decapeptide (10–19), and the resulting protected tricosapeptide amide (10–32) was reacted with the N‐terminal protected nonapeptide (1–9). After elimination of the protective groups, a free dotriacontapeptide amide was obtained whose physical, chemical and biological behaviour was indistinguishable from that of the natural hormone.
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Guttmann et al. (1968) studied this question.
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