Answers are grounded in this paper and cite their sources.
The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary complex. What do we know now that we did not know before this structural information was available, and how do these new data help us to develop new therapies?
No takes yet. Share an insight, caveat, or question.
Kendall A. Smith (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: