Gaps and Challenges in Microdosimetry: Improvements With Realistic Models of Endoplasmic Reticulum

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In bioelectromagnetics it can be crucial to estimate electric quantities at the microscopic scale, to establish a connection between the external applied field and the observed effects. Here we present a microdosimetric study based on a 2D realistic model of a cell and its endoplasmic reticulum. The analysis is quantified in terms of electric field and transmembrane potential induced by an external applied 10 ns pulsed electric field. This study opens the way to numerically assisted experiments for control and biomanipulation of cells and subcellular organelles.