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The tetracyclic furocoumarin 2H‐benzofuro[3,2‐g]‐1‐benzo‐pyran‐2‐one and its 4 and/or II methyl analogues have been investigated in their DN A‐photobinding properties. Spectrophotometric and radioactivity measurements show that these compounds exhibit prominent ability to bind to the polynucleotide double helix by covalent photoaddition of the furocoumarin 3,4 double bond. Denaturation‐renaturation experiments demonstrate that no cross‐link of DNA chains occurs. Benzopsoralens can thus be considered as a new class of monofunctional DNA‐photobinding agents.
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Palumbo et al. (1986) studied this question.
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