Effect of chlorhexidine gluconate on granulation tissue

A well defined cavity surrounded by granulation tissue was created by subcutaneous implantation of perforated Teflon® cylinders. A 0.2 % solution of chlorhexidine digluconate or physiological saline was injected into the cavity five and ten days after the implantation. The acute inflammatory reaction in the recipient area was estimated from the amount of exudate and the number of inflammatory cells in the cylinder cavity. The recipient tissue was also examined histologically. The injection of chlorhexidine resulted in a slightly larger increase of the acute inflammation than did saline. Furthermore, after injection of chlorhexidine the fluid‐filled area of the cavity showed stroma of precipitated material.