Key result
Following HSCT and a physical therapy protocol, patients experienced decreases in right and left dynamometry (p≤0.0001 and p=0.002) and 6MWT distance (p=0.004) compared to baseline.
Why the study?
The study was conducted to analyze the effects of a hospital cardiorespiratory physical therapy protocol on functional capacity and quality of life in patients undergoing hematopoietic stem cell transplantation.
Does a cardiorespiratory physical therapy protocol preserve functional capacity and quality of life in patients undergoing hematopoietic stem cell transplantation?
Does a cardiorespiratory physical therapy protocol preserve functional capacity and quality of life in patients undergoing hematopoietic stem cell transplantation?
A cardiorespiratory physical therapy protocol during HSCT hospitalization may help preserve respiratory muscle strength and quality of life, although declines in peripheral muscle strength and aerobic capacity still occur.
Peripheral declines persist post-HSCT despite PT; leaves open whether protocol preserves respiratory strength or QoL.
OBJECTIVE: To analyze the effects of hospital cardiorespiratory physical therapy protocol on the functional capacity and quality of life of patients submitted to hematopoietic stem cell transplantation (HSCT). METHODS: From January to December 2019, bilateral dynamometry, Manovacuometry and Ventilometry, peak expiratory flow "Peak Flow", 6-min walk test (6MWT), SF-36 Quality of Life Questionnaire and Visual Analog Scale (VAS) were applied in patients who have undergone an allogeneic or autologous hematopoietic stem cell transplantation (HSCT), pre-conditioning (initial evaluation) and pre-discharge (final evaluation). The patients were submitted to an intervention protocol, consisting of aerobic training, muscle strengthening and respiratory muscle training, between the two assessments. RESULTS: 29 patients were enrolled in the study and 24 (83%) completed all procedure. Myeloablative and reduced intensity conditioning were performed in 89.6% and 10.4%, respectively; 17 (58%) patients have undergone an autologous HSCT; 10 (35%) identical related allogeneic HSCT, and 2 (7%) haploidentical allogeneic HSCT. The median number of interventions per patient was 3 (1-9). A decreasing in the right and left dynamometry (p ≤ 0.0001 and 0.002, respectively) and, also in the distance covered in the 6MWT (p = 0.004), was observed after HSCT. There was no significant difference in respiratory muscle strength, quality of life and fatigue sensation. CONCLUSION: Cardiorespiratory rehabilitation can preserve functional capacity and quality of life.
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Morais et al. (2021) studied Hematopoietic stem cell transplantation (HSCT) (n=29). Cardiorespiratory physical therapy protocol vs. Baseline (pre-conditioning) was evaluated on Right and left dynamometry and 6-min walk test (6MWT) distance (p=≤0.0001). Following HSCT and a physical therapy protocol, patients experienced decreases in right and left dynamometry (p≤0.0001 and p=0.002) and 6MWT distance (p=0.004) compared to baseline.
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