Exploration into the dienophilicity of indole in inverse electron demand Diels-Alder reactions has led to the development of the triazatetracyclo[7.7.0.0 1,13 .0 2,7]hexadeca-2,4,6,10,12-pentaene and related scaffolds for diversification in the search for new, biologically active compounds.The libraries constructed from these core structures have lead to the discovery of new anti-viral and anti-malarial compounds.
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Snyder et al. (2011) studied this question.
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