Key result
Bupivacaine-induced spinal block at the level of T8-T9 reduced the ED50 of propofol by 39% in men undergoing lower abdominal, pelvic or lower limb surgery.
Why the study?
Does bupivacaine-induced spinal block reduce the hypnotic requirement of propofol in men undergoing lower abdominal, pelvic, or lower limb surgery?
Population
105 men undergoing lower abdominal, pelvic or lower limb surgery
Comparison
Propofol combined with either… vs Propofol alone
Design
Other
Authors
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May support lower propofol dosing with T8-T9 spinal block; leaves open confirmation in randomized trials and outcome effects.
RCT (n=105)
Does bupivacaine-induced spinal block reduce the hypnotic requirement of propofol in men undergoing lower abdominal, pelvic, or lower limb surgery?
Effect estimate: 39% reduction
Bupivacaine-induced spinal block significantly reduces the hypnotic dose requirement of propofol, likely due to reduced afferent input.
Tverskoy et al. (1996) conducted an RCT in Lower abdominal, pelvic or lower limb surgery (n=105). Bupivacaine-induced spinal block vs. Propofol alone or with intramuscular bupivacaine 12.5 mg was evaluated on ED50 of propofol (39% reduction). Bupivacaine-induced spinal block at the level of T8-T9 reduced the ED50 of propofol by 39% in men undergoing lower abdominal, pelvic or lower limb surgery.
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