Anti-angiogenic Activities of Novel Isocoumarins, AGI-7 and Sescandelin.

Angiogenesis is a fundamental process by which new blood vessels are formed and is composedof several steps including proteolytic degradation of basement membrane in the vessels, directed migration and proliferation of endothelial cells to provide cells for the new vessels. In adults, angiogenesis occurs under several physiological conditions including maturation of the corpus luteum, inflammation, wound healing and delayed hypersensitivity reactions, however, uncontrolled angiogenesis can contribute to a numberof pathological processes such as rheumatoid arthritis, diabetic retinopathy and tumor growth and metastasis.1} Thus anti-angiogenic therapy was