Key result
Apoptosis dysregulation may play a significant role in HIV-associated cardiomyopathies, similar to its known role in ischemia/reperfusion and heart failure.
The review highlights the potential role of apoptosis in HIV-associated cardiomyopathies, drawing parallels with ischemia/reperfusion and heart failure.
Hypothesis-generating for apoptosis-targeted therapies in HIV cardiomyopathy; prospective trials needed before clinical consideration.
Cardiomyopathies are observed with increasing frequency in association with AIDS and HIV infection. Although indirect evidence exists suggesting an association between apoptosis regulation and HIV infection, there is yet no direct evidence that HIV-associated cardiomyopathies involve increased level of apoptosis in the heart. However, since it is now known that apoptosis plays a significant role in heart injury associated with other conditions such as ischemia/reperfusion and heart failure, there is a possibility that dysregulation of apoptosis plays a similarly important role in HIV-associate cardiomyopathies. Here we will briefly review the evidence that apoptotic death of cardiomyocytes occurs and what novel therapeutic strategies may be suggested.
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Tomei et al. (2001) conducted a review in HIV-associated cardiomyopathies. Apoptosis was evaluated. Apoptosis dysregulation may play a significant role in HIV-associated cardiomyopathies, similar to its known role in ischemia/reperfusion and heart failure.
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