Parallel Solution-Phase Synthesis of Acrylonitrile Scaffolds Carrying l -α-Amino Acidic or d -Glycosyl Residues

A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.