Corticotropin (Acth) in Lethal Granuloma of the Nose and Face

TREATMENT with corticotropin in the case being presented gave such dramatic results that it has seemed worth while to make a brief report. For years malignant (lethal) granuloma of the nose has resulted in a fatal outcome, in spite of what was done for the patient. Fortunately, encouraging results have appeared recently. Williams and Hochfilzer,1in 1950, and Paul Moore and his associates,2in 1951, reported successful treatment of idiopathic granuloma of the face with cortisone. In 1933 Patrick Dempsey,3of Dublin, reported on "Nasal Granulomata" and under the heading of "malignant granuloma" recorded seven cases found in the literature up to that time. He stated that it is a tumor of unknown etiology, due to no visible organism, made up of granulation tissue, and malignant in its behavior. Syphilis was usually thought to be the cause of the condition, but the Wassermann reaction was negative, and antisyphilitic and local treatment