Key result
Celiac plexus neurolysis induced persistent orthostatic hypotension in 50% of patients, an exaggerated postural heart rate increase in 18.75%, and both in 6.25%.
Why the study?
Celiac plexus neurolysis has been linked to orthostatic hypotension, but persistent hemodynamic changes beyond the immediate postprocedural period have not been quantified prospectively.
Does celiac plexus neurolysis cause persistent orthostatic hemodynamic changes in patients with cancer?
Observational (n=16)
Does celiac plexus neurolysis cause persistent orthostatic hemodynamic changes in patients with cancer?
Celiac plexus neurolysis in cancer patients is associated with a high incidence of persistent orthostatic hypotension and exaggerated postural heart rate increase, which may be poorly tolerated.
Celiac plexus neurolysis may be associated with persistent orthostatic changes in cancer patients; this case report leaves open confirmation of incidence and impact.
Celiac plexus neurolysis has been associated with orthostatic hypotension but has not been quantified prospectively or evaluated for persistence after the immediate postprocedural period. Our objective was to quantify persistent hemodynamic changes induced by celiac plexus neurolysis. In this case series of 16 patients with cancer, 8 (50%) had orthostatic hypotension alone, 3 (18.75%) developed an exaggerated postural heart rate increase (>30 beats per min), and 1 (6.25%) had both orthostatic hypotension and an increased heart rate. While the analgesic benefit of celiac plexus neurolysis is clear, the observed hemodynamic changes may be poorly tolerated in some individuals.
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Brogan et al. (2021) conducted an observational in Cancer (n=16). Celiac plexus neurolysis was evaluated on Persistent hemodynamic changes (orthostatic hypotension and exaggerated postural heart rate increase). Celiac plexus neurolysis induced persistent orthostatic hypotension in 50% of patients, an exaggerated postural heart rate increase in 18.75%, and both in 6.25%.
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