Key result
Spironolactone significantly attenuated rapid atrial pacing-induced atrial electrical and structural remodeling in rabbits, preserving AERP frequency adaptability and L-type calcium channel expression.
Why the study?
Does spironolactone prevent rapid pacing-induced atrial remodeling in a rabbit model?
Does spironolactone prevent rapid pacing-induced atrial remodeling in a rabbit model?
Spironolactone attenuates acute atrial electrical and structural remodeling induced by rapid atrial pacing in a rabbit model, suggesting a potential role in preventing atrial fibrillation progression.
Spironolactone effects in rabbit RAP remodeling should not yet change practice; leaves open human AF translation.
This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1(st), 2(nd), 4(th), 6(th) and 8(th) of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAP-induced atrial remodeling.
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Wang Lian-fa (2016) studied Atrial fibrillation (Atrial remodeling) (n=30). Spironolactone vs. Rapid atrial pacing with saline was evaluated on AERP frequency adaptability (AERP200-AERP150) at 8 hours (p=<0.05). Spironolactone significantly attenuated rapid atrial pacing-induced atrial electrical and structural remodeling in rabbits, preserving AERP frequency adaptability and L-type calcium channel expression.
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