Key result
Dietary L-tyrosine supplementation (250 to 3000 mg/day) in 5 patients with nemaline myopathy was associated with decreased sialorrhoea, increased energy levels, and improved strength.
Why the study?
Does dietary L-tyrosine supplementation improve symptoms in patients with nemaline myopathy?
Case Report (n=5)
Does dietary L-tyrosine supplementation improve symptoms in patients with nemaline myopathy?
Dietary L-tyrosine supplementation may improve bulbar function, activity levels, and exercise tolerance in patients with nemaline myopathy.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for L-tyrosine in nemaline myopathy; prospective trials needed before clinical adoption.
Nemaline myopathy is defined by the presence of nemaline bodies, or rods, on muscle biopsy. Facial and bulbar weakness in nemaline myopathy cause chewing and swallowing difficulties, recurrent aspiration, and poor control of oral secretions. This article discusses 5 patients (4 infants and 1 adolescent) with nemaline myopathy who received dietary supplementation with L-tyrosine (250 to 3000 mg/day). All 4 infants were reported to have an initial decrease in sialorrhoea and an increase in energy levels. The adolescent showed improved strength and exercise tolerance. No adverse effects of treatment were observed. Dietary tyrosine supplementation may improve bulbar function, activity levels, and exercise tolerance in nemaline myopathy.
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Ryan et al. (2007) conducted a case report in Nemaline myopathy (n=5). Dietary L-tyrosine supplementation was evaluated on Clinical improvement (sialorrhoea, energy levels, strength, exercise tolerance). Dietary L-tyrosine supplementation (250 to 3000 mg/day) in 5 patients with nemaline myopathy was associated with decreased sialorrhoea, increased energy levels, and improved strength.
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