Key result
CHAP is expressed in striated muscle during embryonic development and in smooth muscle cells of the aorta, carotid, and coronary arteries in adult mice.
Key points are not available for this paper at this time.
CHAP expression in mice does not inform clinical decisions; leaves open its role in human vascular development.
We recently identified a new Z-disc protein, CHAP (Cytoskeletal Heart-enriched Actin-associated Protein), which is expressed in striated muscle and plays an important role during embryonic muscle development in mouse and zebrafish. Here, we confirm and further extend these findings by (i) the identification and characterization of the CHAP orthologue in chick and (ii) providing a detailed analysis of CHAP expression in mouse during embryonic and adult stages. Chick CHAP contains a PDZ domain and a nuclear localization signal, resembling the human and mouse CHAPa. CHAP is expressed in the developing heart and somites, as well as muscle precursors of the limb buds in mouse and chick embryos. CHAP expression in heart and skeletal muscle is maintained in adult mice, both in slow and fast muscle fibers. Moreover, besides expression in striated muscle, we demonstrate that CHAP is expressed in smooth muscle cells of aorta, carotid and coronary arteries in adult mice, but not during embryonic development.
No takes yet. Share an insight, caveat, or question.
Eldik et al. (2011) studied this question. CHAP is expressed in striated muscle during embryonic development and in smooth muscle cells of the aorta, carotid, and coronary arteries in adult mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: