Key result
Higher current BMI was significantly associated with a lower mortality risk (HR 0.61 per 5 kg/m2 increase) in Japanese patients with critical limb ischemia, whereas maximum past BMI was not.
Why the study?
Past history of obesity or maximum BMI predicts prognosis in the general population, but their distribution and prognostic impact in patients with critical limb ischemia undergoing revascularization were unknown.
Does current or maximum BMI impact prognosis in Japanese patients with critical limb ischemia undergoing revascularization?
Observational (n=499)
Yes
Does current or maximum BMI impact prognosis in Japanese patients with critical limb ischemia undergoing revascularization?
In Japanese patients with critical limb ischemia undergoing revascularization, current obesity is uncommon (18%), and maximum BMI is not independently associated with mortality risk.
Answers are grounded in this paper and cite their sources.
Current BMI inversely predicts mortality after CLI revascularization; leaves open whether maximum BMI extends general-population prognostic value.
AIM: Recent studies suggested that past history of obesity or maximum body mass index (BMI) in the past was a strong prognostic predictor in a general population. The current study aimed to survey the distribution of current and maximum BMIs and to investigate their prognostic impact in patients with critical limb ischemia (CLI), whose prognosis was poor even after revascularization. METHODS: We analyzed a database of a prospective, multicenter registry in Japan, including 499 CLI patients undergoing revascularization. Their current and maximum BMIs were surveyed at registration. The distribution and the impact on the prognosis were explored. RESULTS: increase were 0.61 [0.46, 0.81] (P=0.001) and 1.07 [0.87, 1.31] (P=0.55), respectively. CONCLUSION: The prevalence of current obesity was as low as 18% (15% to 22%) in Japanese CLI patients undergoing revascularization, whereas about a half were formerly obese. Maximum BMI was not independently associated with the mortality risk in the population.
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Takahara et al. (2020) conducted an observational in Critical limb ischemia (n=499). Current body mass index (BMI) was evaluated on Mortality risk (per 5 kg/m2 increase in current BMI) (HR 0.61, 95% CI 0.46-0.81, p=<0.001). Higher current BMI was significantly associated with a lower mortality risk (HR 0.61 per 5 kg/m2 increase) in Japanese patients with critical limb ischemia, whereas maximum past BMI was not.
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