Therapeutic use of cutaneously applied DMSO demands thorough knowledge of resorption, distribution, storage, elimination, and metabolic pathways in man and animals.S-and 3H-labeled DMSO was used to elucidate these factors.Our results cover the unchanged DMSO as well as its metabolite, DMS02, which was described by Gerhards and Gibian.Unless indicated otherwise, DMSO as a 9OT solution was used for the experiments.
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Kolb et al. (1967) studied this question.
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