Key result
In mammalian skeletal muscles, phosphoglycerate mutase localizes mainly at the M-line but accumulates within the I-band under contracting conditions, interacting with triose phosphate metabolism enzymes.
Key points are not available for this paper at this time.
No immediate clinical implications; leaves open whether dynamic localization modulates muscle metabolism or contraction in vivo.
Contrary to previously published data, we have found that in mammalian skeletal muscles, phosphoglycerate mutase (PGM) is organized in a regular, striated fashion within the sarcomere. In the absence of the enzyme effectors, PGM localizes mainly at the M-line, but under conditions typical for contracting muscle, the enzyme accumulates within the I-band of the sarcomere. Searching for muscle PGM binding partners, we have found that PGM interacts with several enzymes of triose phosphate metabolism. It might suggest that PGM is a central structural element of the muscle glycolytic complex located within the isotropic region of the sarcomere.
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Kowalski et al. (2009) studied this question. In mammalian skeletal muscles, phosphoglycerate mutase localizes mainly at the M-line but accumulates within the I-band under contracting conditions, interacting with triose phosphate metabolism enzymes.
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