Novel Highly Substituted Biraryl Ethers, Phomosines D–G, Isolated from the Endophytic Fungus Phomopsis sp. from Adenocarpus foliolosus

Six new metabolites, phomosines D–G (4–7), 6‐hydroxy‐6‐isopropylcyclohex‐1‐enecarboxylic acid (8) and(1aS,3R,4R,4aR,6S,7R,8aS)‐7‐chloro‐3,6‐dihydroxy‐3,4a,8,8‐tetramethyl‐octahydro‐1aH‐naphtho[1‐b]oxirene‐4‐carboxylic acid (9) were isolated together with seven known compounds (1–3, 10–13) from the endophytic fungus Phomopsis sp. The structures of 1–13 were determined by spectroscopic methods (mainly extensive 1D and 2D NMR experiments and by mass spectrometric measurements). The antibacterial, fungicidal, and herbicidal properties of the new compounds were evaluated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)