Key result
Prostaglandin E1 was rapidly biotransformed by isolated, perfused dog kidneys into three less polar metabolites, with an average of 43% converted into metabolite I during a single passage.
The dog kidney rapidly biotransforms prostaglandin E1 into three less polar metabolites.
Alerts to possible extensive first-pass renal metabolism of PGE1; leaves open relevance to human pharmacokinetics and dosing.
The biotransformation of prostaglandin E(1) (PGE(1)) was studied in the isolated, perfused dog kidneys.2. An average 43% of PGE(1) was converted into the less polar metabolite I by a single passage through the kidney. As the re-circulation of the perfusate continued, PGE(1) was converted not only into metabolite I but also the least polar metabolite II. The velocity of the conversion of PGE(1) into metabolite I was significantly greater than that into metabolite II. Usually, six passages elapsed before maximum degradation of PGE(1) occurred.3. Further separation with silicic acid column chromatography and gas-liquid chromatography showed that metabolite II consists of two individual metabolites, metabolite IIa and metabolite IIb.4. The present study indicates that the kidney biotransforms PGE(1) rather rapidly into three metabolites which are less polar than PGE(1).
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Jiro Nakano (1970) studied this question. Prostaglandin E1 (PGE1) was evaluated on Biotransformation of PGE1. Prostaglandin E1 was rapidly biotransformed by isolated, perfused dog kidneys into three less polar metabolites, with an average of 43% converted into metabolite I during a single passage.
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