Synthese von (+)‐Aspicilin mit Bausteinen aus nachwachsenden Rohstoffen

Synthesis of (+)‐Aspicilin Using Building Blocks from Renewable Resources The 18‐membered lichen macrolide (+)‐aspicilin (1) is easily built up from compounds 14, 16, 3, and 24 following the C3 + C7 + C6 + C2 = C18 pattern (see Schemes). The synthesis requires 15 steps and gives 1 in 13% overall yield from D‐mannose (2). The latter compound provides the stereogenic centers C(4), C(5), and C(6). The stereogenic center C(17) is supplied by building block 14 (from (−)‐(S)‐ethyl lactate).