Key result
Idiopathic dilated cardiomyopathy was associated with significantly higher daily alcohol consumption compared to coronary artery disease controls (82 g/day vs. 30 g/day, P < 0.0002).
Why the study?
Is alcohol consumption and biological markers for alcoholism associated with idiopathic dilated cardiomyopathy compared to coronary artery disease?
Case-Control (n=69)
Is alcohol consumption and biological markers for alcoholism associated with idiopathic dilated cardiomyopathy compared to coronary artery disease?
Absolute Event Rate: 82% vs 30%
p-value: p=< 0.0002
Alcohol consumption is strongly linked to idiopathic dilated cardiomyopathy in this French population, though biological markers are poor predictors of alcohol intoxication.
Supports alcohol history assessment in dilated cardiomyopathy; leaves open causality and need for prospective studies.
The aim of this study was to compare alcohol consumption and biological markers for alcoholism in a population of 23 men (57 +/- 8 years) admitted to hospital with idiopathic dilated cardiomyopathy (DCM), and a control group of 46 men (54 +/- 8 years) with coronary artery disease, matched for age. The DCM group had a higher daily alcohol consumption (82 g/day vs. 30 g/day, P < 0.0002). This difference was greater for the consumption of wine (63 g/day in the DCM group vs. 24 g/day in the control group, P < 0.002). Duration of regular daily alcohol consumption was longer in DCM patients (34 years vs. 22 years, P < 0.01) as well as duration of heavy alcohol consumption (> 60 g/day) (25 years vs. 10 years, P < 0.001). Among the biological markers, only the serum levels of immunoglobulin A were significantly increased in the DCM group (3.7 g/l vs. 2.7 g/l, P < 0.03). In this French population, alcohol is strongly linked to DCM. Biological markers appear to be poor predictors of alcohol intoxication in this so-called 'idiopathic' myocardial disease.
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Gillet et al. (1992) conducted a case-control in Idiopathic dilated cardiomyopathy (n=69). Alcohol consumption vs. Men with coronary artery disease was evaluated on Daily alcohol consumption (g/day) (p=< 0.0002). Idiopathic dilated cardiomyopathy was associated with significantly higher daily alcohol consumption compared to coronary artery disease controls (82 g/day vs. 30 g/day, P < 0.0002).
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