Examine your zipper: An artificial receptor system composed of an extracellular leucine-zipper domain (red helices) fused to the transmembrane and cytoplasmic domains of the epidermal growth factor receptor (EGFR) is shown (see scheme). Dimerization and activation of the receptor is induced by a bivalent leucine-zipper ligand (blue helices), leading to phosphorylation of the cytoplasmic domain of the receptor, and eliciting a signaling cascade.
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Nakase et al. (2012) studied this question.
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